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Early-stage blood testing startups are performing liquid biopsies and testing for biomarkers to identify disease and aid prevention efforts.

Theranos is by far the most recognizable name in the blood testing industry and in early 2015 the company was flying high.

Then, on October 16th, 2015, an investigation by the Wall Street Journal raised questions regarding the state of Theranos’ technology. This was followed by federal investigations, sanctions, and lawsuits.

In this post we take a look at other early-stage blood testing startups funded since the release of the WSJ report, to show where investors are seeing opportunity in blood testing tech, despite the scandal. Some of the early-stage startups being funded are tackling major issues in healthcare ranging from lung and colon cancer to Alzheimer’s disease. Within the group, five healthcare specialties stood out:

  • Oncology: Grail, Clinical Genomics, CellMax Life, 20/20 GeneSystems, Acuamark Diagnostics, & X-Zell
  • Neurodegenerative disorders: Pre Diagnostics
  • Chronic disease: Brainshake
  • Pregnancy: Metabolomic Diagnostics
  • Other: BBB Technologies, Werlabs, & InnaMed

Using the CB Insights platform, we identified 12 early-stage blood testing startups which received seed or Series A funding since October 17th, 2015, and ranked them by total funding received. None have yet received a Series B. Scroll down to see the full list.

 

1. Grail

grail

 

Grail is developing a cancer detection platform intended to directly measure circulating tumor DNA (ctDNA) in the blood, a process referred to as a liquid biopsy. Liquid biopsy technology has the potential to reduce the number of patients diagnosed with late-stage cancers by offering a more scalable, and less invasive, screening option. The company intends to be able to diagnose all cancers.

Select investors: ARCH Venture Partners, Bezos Expeditions, Bill Gates, Google Ventures, Illumina, Sutter Hill Ventures

Total disclosed funding: $100M

 

2. Clinical Genomics

clinical genomics

 

Clinical Genomics has developed a blood test specific for colorectal cancer called Colvera. Similar to Grail, the product will detect the presence of two cancer-associated genes in circulating blood. The test will be used to determine cancer recurrence in patients previously diagnosed with colorectal cancer.

Select investors: OneVentures

Total disclosed funding: $15M

 

3. CellMax Life

cellmax

 

CellMax Life provides a multi-biomarker cancer blood test that surveys for an increased genetic risk of 24 cancers including lung, colorectal, and prostate. The company’s flagship product, announced in November 2016, is CellMax CRC-Protect, a multi-biomarker blood test for early detection of colorectal cancer, which is currently marketed in Taiwan. CellMax life also provides a saliva-based genetic cancer test.

Select investors: Artiman Ventures, Stan Shih (former chairman of Acer, Inc.)
Total disclosed funding: $9M

 

4. 20/20 GeneSystems

2020 gene systems

 

20/20 GeneSystems developed a blood test to aid in early detection of lung cancer using a combined panel of four biomarkers. The test reports results using a risk score, based on the patient’s health data, risk factors, and blood test results which provides physicians insight on the likelihood that the patient has lung cancer. The company is currently developing a similar blood test for the Asian markets.

Select investors: National Cancer Institute, Keiretsu Forum, Ping An Ventures, Undisclosed Angel Investors

Total disclosed funding: $8.25M

 

5. Brainshake

brainshake

 

Brainshake is a Finland-based blood testing company targeting the chronic disease market. The company provides a blood testing platform that simultaneously analyzes over 220 metabolic biomarkers such as cholesterol, lipids and amino acids. This method may allow for greater scalability of preventative medicine measures such as metabolic panels.

Select investors: COR Group, TJP Consulting, Finnvera, Nordea Bank, Tekes

Total disclosed funding: $6.24M

 

6. BBB Technologies

bbb tech

 

BBB Technologies developed a mobile-enabled blood testing device and integrated app called Elemark. The platform includes features such as gamification, alerts, and messaging to remind patients to administer their blood tests. The tests are conducted at home by the patients and data is shared with the physician. This platform will allow for greater regularity of blood testing and is of particular relevance to chronic disease patients and the research community.

Select investors: ID Ventures, Mirae Asset Ventures, POSCO Venture Capital

Total disclosed funding: $5.02M

 

7. Werlabs

werlabs

 

Werlabs is a Sweden-based company providing a patient-centered approach to blood testing. The company allows the customer to order a blood test at a service center, which generates a referral, take the blood to a local testing site, and receive the results online within hours or days. The company enables consumers to take a hands-on approach to healthcare.

Select investors: 3TInvest, Sunstone Capital, multiple angel investors

Total disclosed funding: $4.28M

8. Metabolomic Diagnostics

metabolic

 

Metabolomic Diagnostics is an Ireland-based company working on a blood test, administered at 15 weeks into pregnancy, to determine the risk of a woman developing preclampsia later in her pregnancy. Preclampsia is a potentially fatal disease of pregnancy identified by hypertension and protein in the urine. It often results in premature births. The company is currently working to validate and commercially develop the platform.

Select investors: SOSVentures, Enterprise Ireland, Enterprise Equity Limited, AIB Seed Capital Fund

Total disclosed funding: $3.84M

 

9. Pre Diagnostics

prediagnostics

 

Pre Diagnostics is developing a blood-based diagnostic test for Alzheimer’s disease. Based on the discovery of a new biomarker, the company hopes to be able to diagnose Alzheimer’s in its early stages, before the onset of symptoms. There is currently no such test on the market. The company is planning to release a research-only version of the test in 2017.

Select investors: Undisclosed

Total disclosed funding: $1.6M

 

10. Acuamark Diagnostics

acuamark

 

Acuamark Diagnostics provides a blood-based screening solution for early cancer detection. The company currently provides two tests, the Eagle i5 and the Eagle iSEQ, the former of which detects cancer biomarkers such as genetic mutations and the later sequences DNA pulled directly from blood plasma. The company is initially targeting colon cancer but plans to detect the majority of all major cancers in the early stages.

Select investors: NGN Capital

Total disclosed funding: $1.48M

11. X-Zell

xzell

 

X-Zell is an early cancer detection blood testing company that demoed at Y Combinator’s Winter 2016 Demo Day 2 in March. The company states an over 90% success rate.

Select investors: Y Combinator

Total disclosed funding: $120K

 

12. InnaMed

innamed

 

InnaMed develops cloud and mobile-connected blood-testing products intended to be used at home. “Cards” with micro-needle technology will be used to collect blood samples which are then inserted into a device called the HealthScale to be interpreted. The company intends to produce 5 cards focused on chronic disease management, fitness tracking, general health, fertility and pregnancy, and infection disease diagnostics.

Select investors: Boomtown Accelerator

Total disclosed funding: $20k

[CB Insights]