Winners of the 2014 William B. Coley Award for Distinguished Research in Tumor Immunology discuss their contributions to the discovery of the PD-1 immune checkpoint and its role in cancer immunotherapy. Featuring Arlene Sharpe, M.D., Ph.D., of Harvard Medical School; Gordon Freeman, Ph.D., of Dana-Farber Cancer Institute; Tasuku Honjo, M.D., Ph.D., of Kyoto University School of Medicine; and Lieping Chen, M.D., Ph.D., of Yale University School of Medicine. The William B. Coley Award is given annually to scientists who have made important contributions to basic or tumor immunology, and is the highest honor bestowed by the Cancer Research Institute. Photos of Dr. Chen courtesy of Harold Shapiro.

 

Dan Chen MD, PhD from Stanford Medical Oncology and Genentech describes brilliantly how our immune system detects cancer cells and how tumors get past our immune system through PD-L1, PD-1, and B7.1 interactions. A must see!!! Brilliant way to understand the effects of checkpoint inhibitors and cancer immunotherapy.